The leaders called for an worldwide probe while condemning the use of chemical weapons in Syria, Saudi Foreign Minister Adel al-Jubeir told reporters after the summit.
Adel al-Jubeir was speaking at a news conference after the end of an Arab League summit in Saudi Arabia, which had not mentioned Syria in a statement read out at the close.
The summit took place in Saudi Arabia on Sunday, a day after the coordinated attacks by the US, UK and France on three sites allegedly linked to the production of chemical weapons in Syria.
"We stress our absolute condemnation of the use of chemical weapons against the sisterly Syrian people and we demand an independent global investigation to guarantee the application of worldwide law to everyone proven to use chemical weapons", said its final statement.
But the leaders were divided over the US-led air strikes against Syria.
Riyadh expressed its support for the strikes on Damascus in a statement on Saturday.
"We hold the Iran-backed Houthi militias fully responsible for the emergence and continuation of the Yemeni crisis and the human suffering that has afflicted Yemen", the King Said.
Saudi Arabia, which takes over the rotating chair of the Arab summit from Jordan, announced that this gathering would be named the "Quds (Jerusalem) Summit", a reference to US President Donald Trump's decision previous year to recognize Jerusalem as the capital of Israel, which Arab states condemned.
Kathua Rape: Justice will be served, says Jammu Police
The 08-year-old girl was held captive in a temple, sedated and gang-raped multiple times before being murdered by the accused. Lawmakers also voted to lower, to 16 from 18, the age at which a person can be tried as an adult for heinous crimes.
The Saudi decisions reflect the Kingdom's strong support to the Palestinian cause and hopefully would lead to the realization of the dream for an independent Palestine state within the 1967 borders and Eastern Jerusalem as the capital for the future country, said OIC chief.
The stand-off between Qatar and Saudi Arabia, UAE, Bahrain and Egypt is also not expected to feature.
The four countries severed diplomatic and transport ties with Doha in June 2017, accusing it of supporting terrorism.
Unveiled during the opening of the Dhahran-hosted 29th Arab summit, the donation will be dedicated to maintenance of Islamic heritage in the city. Doha denies the charges.
In a statement on Sunday, Bahram Qassemi reiterated Iran's principled policy of non-interference in the internal affairs of other countries.
The Arab League was founded in 1945 to protect newly-won independence throughout the region.
Sheikh Tamim returned to Doha on Saturday from a USA trip where he met Trump. "It's a very, very small problem".
Summits of the Arab League, established in 1945, rarely result in action.