Arsenal eventually won the game 3-0 against Watford, with goals from Aubameyang (59minutes) and Mkhitaryan (77minutes) to give the Gunners the deserved three points.
The former Czech global saved Troy Deeney's penalty to become the first ever Premier League goalkeeper to go 200 games without conceding, after Ainsley Maitland-Niles' clumsy challenge on Roberto Pereyra inside the Arsenal box.
With 13 minutes to go, Mkhitaryan sealed the victory- his first league goal for Arsenal- with a shot from inside the box following Aubameyang's pass.
Wenger made six changes to the side that beat AC Milan on Thursday night in the San Siro. I like the two situations because in the first he showed a lot of humility and responsibility and a record like that needs motivation and a huge level of intelligence. If you are going to make statements such as those, however fun, you really have to demonstrate the size of your own by sticking in a spot kick that could've got his side back in the game.
But the win did little to improve Arsenal's prospects of a top-four finish - which brings qualification for the Champions League - and won't carry much weight with supporters who feel ending Wenger's 22-year reign is the only way to get their club back on track.
Shkodran Mustafi's opening goal was Arsenal's 1,000th at home in the Premier League, making the Gunners just the second team to reach the landmark after Manchester United (1,066).
MI shipped out to West Region, will play Montana in Wichita
How they falter: Bridges and Ward's up-close and personal style backfires, and their scrappiness puts them in foul trouble early. The Tar Heels finished the season with a 25-10 record and lost in the ACC title game.
Watford have now lost all five of their away Premier League matches in the month of March.
But I wanted absolutely to win this game and it was hard, but overall, it gets us a little bit out of that negative spiral that we were in. "We also tried to create chances from set pieces and the counter-attack but if you don't score it's very hard". After a hard Thursday night game, on Sunday morning we still had the spirit to stick together.
"We need more games, we had a nightmare week, overall there is some work still to do".
"I always try to deliver my best in every game as I hope that the team achieves something this season", he added.
Elneny helped Arsenal win the Community Shield in the season's curtain-raiser following a 4-1 shootout win over Chelsea last August.
Watford face a tough trip to Liverpool in their next Premier League fixture.