He is the first Egyptian player to score a Premier League hat trick, and capping a memorable evening, Salah was on hand to slam in his fourth in the 85th minute after Karnezis spilled Danny Ings' shot.
It's a remarkable turn of events for Salah, who struggled on his previous spell in the Premier League.
"I don't think Mo or anybody else wants to be compared with Lionel Messi - he is the one who has been doing what he's been doing for what feels like 20 years or so".
The 25-year-old has scored 28 league goals so far this term - which is more than any other player across Europe's top five leagues.
Jose Mourinho's awesome speech in Man Utd press conference
I can not name them. "I learn in my religious formation, be happy with others" happiness; so be it, I am a really happy guy". They managed just four shots on target in 180 minutes against a team that has conceded 42 league goals this season.
And Liverpool face runaway Premier League leaders Manchester City in a blockbuster Champions League quarter-final early next month.
"The goals we scored were unbelievably good, and the boys didn't stop".
"I said since day one here that I'm happy here at Liverpool and I want to show my football here".
With Tottenham Hotspur and Manchester United not in league action due to their involvement in the FA Cup, it was the ideal opportunity for Jurgen Klopp's men to apply pressure on their rivals and the Reds responded with a dominating performance to prove that they weren't dwelling on last week's loss to the Red Devils.
"[Klopp] changed something in me", Salah told ESPN. The last player I know who had the same influence on a team performance was Diego Maradona. "If you see my goals and everything I did in my last four or five years, every year is better than the year before".