Through examining trials involving almost 120,000 people, including patients taking 21 commonly prescribed antidepressants, the research found all the drugs were more effective than a placebo.
The drugs ranged in effectiveness from one-third more effective than a placebo to more than twice as effective.
What is the controversy behind antidepressants? And, though the meta-analysis is strong, this paper is unlikely to conclusively end the debate over the efficacy of antidepressants.
Antidepressants do work, a major new study has confirmed.
A vast research study which sought to settle a long-standing debate about whether or not antidepressant drugs work has found they are indeed effective in relieving depression.
'We found the most commonly prescribed anti-depressants work for moderate to severe depression and I think this is very good news for patients and clinicians'.
Depression is the single largest contributor to global disability and is a "massive challenge" for humankind, said John Geddes, professor of epidemiological psychiatry at Oxford University (The Guardian). However, there was a big variability in how well they fared.
A large-scale review of the most common antidepressants has found them all to be superior to placebo in treating major depression, potentially laying to rest questions over their effectiveness.
Netanyahu's confidant agrees to testify against him in graft probe
Any actual indictment may be months away, pending a hearing with Netanyahu's lawyers and a decision by the attorney general. Netanyahu, who has led Israel periodically for 12 years since 1996, has repeatedly denied all the allegations against him.
The importance of addressing depression can not be overstated.
In the US, the National Institute of Mental Health estimates 16.2 million adults experienced at least one major depressive episode in 2016.
Accusations of bias on either side are unlikely to go away. The fact that the conclusion "antidepressants work" was considered groundbreaking enough to be published in a reputable science journal says a lot about existing uncertainties in the field.
The worldwide investigation is a system meta-examination of 522 twofold visually impaired, randomized controlled trials involving an aggregate of 116477 members.
Furthermore, several previous trials have cast serious doubts on antidepressants (at least some of them). "(But) this study supports that for patients with a diagnosed condition of depression, antidepressants are useful". The FDA demands pharmaceutical companies provide data on all the clinical trials they sponsor-including unpublished trials. Some people suspect drug companies of fiddling trial results.
We were open to any result.
The report's authors said more people could potentially benefit from taking antidepressants. The creators take note of that the distinction might be on account of melancholy in youngsters is the outcome of various components or causes, and note that as a result of the more modest number of concentrates in youngsters there is extraordinary vulnerability around the dangers and advantages of utilizing any antidepressants for the treatment of sorrow in kids and teenagers.
Lastly, this review only analyzed results over a period of 8 weeks. "The choice will need to be made by doctor and patient". For adults with major depressive disorder, all antidepressants are more efficacious than placebo, according to research published online February 21 in The Lancet.