A Potentially Powerful New Antibiotic Is Discovered in Dirt

Handfuls of soil

Antibiotics family discovered in soil could be the answer to antibiotic resistance

Dr Alderwick, who is director of the Birmingham Drug Discovery Facility as well as a lecturer at Birmingham University, said work by university teams, like the Rockefeller group and his own team, will play a larger role in future antibiotic discovery because pharmaceutical companies have struggled to make money in this area.

To find these molecules, Brady and his colleagues have been using a culture-independent discovery platform that enables them to extract, clone, and sequence DNA from soil samples without having to grow bacteria in the lab.

Of course, looking to the dirt to find antibiotics is not a novel idea.

In experiments with rats, the compound eliminated MRSA infection.

Finding new antibiotics is key to staying one step ahead of bacteria threats, but only one new class - teixobactin - has been discovered in the last 33 years. So instead, they used high-speed computer processing to "screen" the soil samples for the distinctive chemical hallmark of calcium dependence.

Brady says there are at least 10,000 bacteria under each footprint of soil, a lot of them still unidentified. This ability to switch on and off, Brady explained, means they may be able to avoid constantly being exposed to the development of resistance.

12 scientists discovered malacidins, compounds which, based on tests, kill multiple bacterial diseases now resistant to most of our existing antibiotics.

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In a report published this week in the journal Nature Microbiology, researchers describe a never-before-seen antibiotic agent that vanquished several strains of multidrug-resistant bacteria.

Dominant antibiotic fighting against bacterial strains discovered in soil by the researchers from Rockefeller University at the laboratory at Upper East Side of NY. They focused specifically on a clade of genes that are found in 1 of every 10 samples. They hypothesized that the genes responsible for this "calcium-dependent motif" might be found in other compounds. 'This might be a way of reducing resistance'.

The team knew that long after other antibiotics would have stopped being effective, daptomycin continues to kill its targets, and theorized that this unique ability may have something to do with its use of calcium.

Yet, less than a century after Fleming's discovery there are precious few antibiotics left and many superbugs are already resistant to all of them.

With a view to developing the compounds into a real treatment for people, the researchers are now working to improve the drug's effectiveness.

"Now we need to say, 'You guys can do even better, '" Lewis said. "I think this platform gives us some hope that we can go back to this tremendously powerful reservoir we used to look at in the past, and look at it in new ways and find new things", he said.

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