Perched comfortably atop the Premier League table and unbeaten with more than half the schedule behind them, City can be confident of winning the title this season, nevermind finishing well ahead of their weekend hosts.
The Reds have just lost their star man Philippe Coutinho to Barcelona, and though he will be sorely missed, they still have a lot of cutting edge going forward, and van Dijk's arrival will tighten their somewhat questionable defending.
They've scored nine in their last three home games against Premier League opposition, beating Swansea, Leicester, and Everton.
Since losing to Tottenham on October 22, Liverpool are unbeaten in 17 matches in all competitions and 13 in the league, their best run under Jurgen Klopp. However, with the resources at his disposal, plus the possibility of adding even more firepower to his ranks this month, the 4/1 (5.0) could be an interesting bet over the course of the next few months.
Both sides enter the match unbeaten in their last five Premier League games, though this has been a consistent trend for City all season.
But Jurgen Klopp hopes to have him back to face City on Sunday with the Egypt global having already returned to full training.
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It's this approach which Klopp will need his men to get right from the first whistle at Anfield, retaining and turning the ball over in order to deny City's ruthless midfield the chance to fall into their creative stride.
And the Gooner would sooner back Manchester United against City, even though a City victory would work better for United, as some kind of twisted prayer for the protection of that great Arsenal record.
City have not won in the Red half of Merseyside in the league for nearly 15 years.
Kevin #De Bruyne has been central to the Citizens' success so far this campaign, with the playmaker in the form of his life.
The atmosphere at Anfield could make for a very different game. He's leading the way for City this season and looking every bit the part.
Guardiola, who is again set to be without captain Vincent Kompany due to a calf injury, believes the weekend clash will provide another stern examination of his team's big-game pedigree, having seen them pass such tests with flying colours at Stamford Bridge, Old Trafford and Napoli's Stadio San Paolo this term. Questions remain about his suitability for this Liverpool team.