While new manager Sam Allardyce misses the trip due to a medical appointment, a number of youngsters have been included in the squad to take on Apollon Limassol.
Craig Shakespear will take charge of the team but it is not a team that many fans will recognise, even Everton fans.
After that, it's an extremely inexperienced side that makes up the squad for the game in Cyprus.
Asked for an injury update on that pair amid rumours that Sandro, who has made just three Premier League starts since arriving at Everton from Malaga in July, had picked up a knock, Shakespeare replied: "Both of those players haven't travelled".
"We have done that as such with some players getting their debuts".
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A youthful core of Under-23 and Under-18 regulars have also travelled, including 17-year-old defender Michael Collins and Ireland Under-21 global midfielder Harry Charsley.
The Toffees have already been knocked out of the competition and that came two games ago.
The Liverpool Echo has revealed that the 63-year-old will stay in the United Kingdom while the rest of the Toffees' squad fly out to take on Apollon Limassol in the last of their Group E matches.
Alex Denny - England Under-17 global Denny is a ball-winning defensive midfielder by trade, but has also stepped up admirably to fill in at centre-back for David Unsworth's second-string team at times this season.
Michael Collins - Eligible for England, Jamaica and the Republic of Ireland, pacy 17-year-old Collins has been a mainstay at centre-back for Everton Under-18s this campaign, but could play at left-back in Cyprus.