In a note posted to Twitter on Thursday (June 15), Bezos asked for ideas "at the intersection of urgent need and lasting impact".
Mr Bezos has previously invested in longer-term bets like space exploration and kept quieter about other givings.
One facetious response saw someone say: "I could need some money and I would consider it very philanthropic".
"I like long-term - it's a huge lever: Blue Origin, Amazon, Washington Post - all of these are contributing to society and civilization in their own ways", Bezos, also the owner of the Washington Post, wrote in the message.
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This philanthropic approach and the focus on Mary's Place appear to be a departure from some larger projects he has blessed with his household's disposable income. Meanwhile, Microsoft founder Bill Gates, the richest billionaire, had reached $32.9 billion in lifetime giving and Berkshire-Hathaway CEO Warren Buffett had given $25.5 billion as of the end of 2015.
Put differently, he's asking his followers of more than 220,000 for philanthropic ideas, particularly any act that can help people in the "here and now".
For the record, Bezos has a net worth of more than $80 billion, making him the second richest man in the world behind Gates, according to Bloomberg.
Earlier this year, his family committed $35m (£27m) to the Seattle-based Fred Hutchinson Cancer Research Centre.
Bill Gates set the example for tech billionaires with the Bill & Melinda Gates Foundation. With this tweet, Bezos has indicated he may now take a far more public approach to charity. However, the Bezos Family Foundation run by his parents is quite active and regularly donates to various causes.